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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a43fbf0dc486df90f485cdc94321f92b5da5b440119325c7ee7de351a6e70f12' 
  AND token = 'Dmr7cme+AG+j8fNPsesDEsiOSkjsXE6BoBwi8M0vt7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}