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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a22f6729aeb19380a4d510074c0021483ab3bc27bff5fb13ff665ffa41cfb610' 
  AND token = 'Ga52KHt9bDlg8BDIjA5BfV2NRslWzG9sS6n+2Ic3txo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}