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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef4215d0180f90028618891bb31f2b1507eb3567e2e8c63c0e079554636b1827' 
  AND token = '+NVbj4RBY7F1zOXsBEGCoRaSTcZ/EBEiYvrssd0TpFI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}