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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '447974085d7260119060b13f4077495d5889b3d95ab518c5f0affda1be86c8c7' 
  AND token = 'HdcZ7y0yu9Yl09LU+IKQOtxwcsZGf4dFL0Ibww5jFD8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}