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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e18bb60e9104e1740d92d86ef9f52fbd62271235030e624b18e6149cee38b22b' 
  AND token = 'ZDuyG3kWDneIY0L+qkUaUwiq9gXICW/IoBWTOPAncic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}