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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a9fb8ef14ad249e4b8120d49086d82b4e5f429dea9a3cdb71d02cf7e3b354036' 
  AND token = 'TjuyjYvMhRAYKyqv4q2FeCs0jx4xc52SIWtdBhXIyvA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}