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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3d016ef3215cb556e486de48f2a6d30df11b8f1ecd08d1646943998e5f680ae' 
  AND token = 'PODj3HZtrnh3xZMW9w2GlAfo28M7nn2xhWb5ot62haM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}