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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b4914bc0ade94a005cd1b169bcaac8d899b5c9c24478248f9f38d0e23f0bfca' 
  AND token = 'TXl5wzhw2W+eHSkOv31XRt82T9ILBBRXXeVM1rTWI0I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}