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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cacdc47596e2c9f51a1aab5d348086110759d6bd1b96b175ff8c6968c09a3b84' 
  AND token = 'DvDzQ9ENpSeZkUQR+JlemiznCpeQG+QEGT4akhcQnJg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}