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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48abd426b096509b6b56250d8e2373f77d34b51d5b0f0167cf730904041f5044' 
  AND token = 'o2qrQt/ZMA2MLfq78Ux2XAYrZmNEAf5gF1zEhk91HVc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}