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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '367b1bad0ebd3176dc4873fab20b6ba12a7405c3128323e14388b583b6446d5a' 
  AND token = 'R1KW0wY7b7oj2V3pGB2I5vBOPRVvTsWwXqNmuP9vnWM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}