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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '225e176bd04e008fa40d55bf5aa30e62b058ff033189819b62e3ee54627874d1' 
  AND token = '3HuXSH2KCex7iDnjyZ+83Qb4nQAdAKSiAlKRfWuk7/g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}