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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed173ff4d4d42764526473a50163b436e5aa0e7f2f09c180161dd332534f1e23' 
  AND token = 'kS+ywDn3fFAniml66XrgN/e2O8MW6HbC1YCqA99Blt4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}