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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '443a6137f97c0a100232299f1bdbbf0d16f5815b112b8f6c45dc5ff3144e2555' 
  AND token = 'A+F2vzL7tvZ7Hf060EnUYkFvLwZ1snro24Hdyjo9R1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}