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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '135dd4dff10bc15455eac27f59e25ebd11a707d0b511d830f6406172accf88f6' 
  AND token = '01CGXHNJFPymSNSTWG3ysv1RJrxGlLEa0HVWNpPO93c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}