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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a8ea43e8bfd4ccb2d70857c11351731012611ef4433c8e9b3fa0486a4100da' 
  AND token = 'gnel7YCbB3j+MObxczU7B0uI69JIMEhETIak7DtOkaQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}