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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '225e5348fa18111a670e5884d9d85daacfdeb4e7a7446db0a1f68646e547a630' 
  AND token = 'w9Il4d5aGFj+XyyTd2ZT2om5O3JPFmjAQBTNpA6LnoA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}