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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72cbd291f958b0193107e4b27d5ba05dd878f3d43cfd719c01db7206b8395391' 
  AND token = 'rEOV/kHLc1XpoKhdhQoC0R4xBBg0VQZRcZ7zZFdFuis=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}