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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5487ff63979e3b575e76745795e71300ac4d3d37504272106e2ff7adbfb8f8f' 
  AND token = 'Lu/E8U/SBE0tyz5UiQeNttgULm+jNfj2hVGlE+sjYC0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}