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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2131d2f88394be139274e5ff4dc239472b9022e8b9951a30b5e9e31b23b372b4' 
  AND token = 'v0I+bRe/ijYEwm2RYKP+C2Z3diGH+ZBot0oIvSYoJxU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}