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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad4f485c52a04059ff470d47230d7d85cbff4b286202c1c06d7a0875ba317b3f' 
  AND token = 'AvTI2724QPp8Oel20PgUQT58qnVCiKs20v26Do8wT5I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}