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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd465b91df546be7a192f4eb6aa81d92666fc62a4e6d79dcb8d89de67497e51a0' 
  AND token = 'tfPDLP3beSHj6nOUYVoqt0zFeHbynRlLBlxuPapSSsE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}