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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25a0ad77345606e01e240a90bdcd5606cb81f804d85de3073c6dfa0fd795936a' 
  AND token = '3biMwhRiYu4zsWnsJC35YS/3jrzwAv56exfwtUWarH8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}