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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e5b0b49ebea196b30614bdb94ac8e4f76eb94ae31aeffe2071f539d8a302403' 
  AND token = '7/MV0add3VHApuQVC2qv2V+E472ACfttbNlH1sMM7Do=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}