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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f643e5e0bbf9747f2c7fd88c52683fc3549742ecad3e93f4f6d61a3719908322' 
  AND token = 'g0PdAHr2o+hs2eP5etHOWrgsHN381Hby9M1OgYUvULU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}