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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64353cc80fe83b8b2d95f33aaab58261f7178983df371db92b1a726f5823dd11' 
  AND token = 'dTeITwFNNOT+vFdnBrDzPDcO3olCjw9hUFJbSD5XLYw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}