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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9880c4c2a780ae6fbc3ccce2f97e02b8e6b8510059520885b9c2e21ab7cac190' 
  AND token = 'mEiiw1DVBm8qF1TdFyTEq1LQEZGhdvJPOEPb7vMINlg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}