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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8725369c0f60fd81f1869251f5e8fcb3154338180efc2f72f9e577cf1fd0bbd6' 
  AND token = 'u5mhkDSu7vz8c+L1E3d+lrb4AhdBC8k3ia9KULq+rlU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}