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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fede254839b17117b3c2a7b423da2dbc7bf8769d07f1e593924f34844f896e5b' 
  AND token = '0P2Jcg8Y0rH5rctf8Eg2W996hmmq6fjRAB8rhnbHQB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}