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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44b381f4bf0269f329e5f8367622d5699d91bff4a2f2fac04c5170d8ed5338a4' 
  AND token = 'vPuWZOQIIFPQk1Nu++KiHrZ72iS0oTuv8IjTTRIJbLo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}