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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9405334b81d23ca267a1a11079b7f7eeeba3661bd5be75f010a1a7ac6c286549' 
  AND token = 'TaxJaeFcJ2RG3jSZjNERWMgRAVYJ1d9nY94V6ZO1wCU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}