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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf289eed2ca570e2e6a56f98b264724e23df346689cf4e205434f887b388bf78' 
  AND token = 'f73wDYWozpZcLo5ellcJaA0Mft9/WsXp1IHsFGtEZgA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}