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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b89778ae05d05160f5e7e2a561fd8d3a8d104df6258c56b2eb6092536b1b27' 
  AND token = 'ikLh18vhJ9XK7zRczgQgpVqaA7bQ6aNDav4Z3043Ac8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}