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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d9cef39e9ebd50f04c1b946618fc6458c15c3f536fbe227b51913a9dd284b4' 
  AND token = '78Md8/GyRZ/evcg92YcaY8uwzCNJUFdO0+fuwIFzUSo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}