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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef5f8642e190925a8ef7d79e230e3def8ce72f3e60d300726afb30b51ad8021a' 
  AND token = 'ZAdEKeU2WpkRjTZFwBmooHiIRnpK3G/WAFH/8n+4OuA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}