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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '646386fac122bdc141e5a437a8e0eae2fa8cfcff5e15090f7740f23abb5d3403' 
  AND token = 'T4vaS88Tn6mKi5q9IMYtzM6aBt1LUsyBw0e6WMYbxWI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}