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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e6618d4d48e360b9394473cb8b3843aa452b204694d3e57d70f359635bf64099' 
  AND token = 'EN+xQECxsJ+s1gzdNgcE2tyPOCtvqXZL7nRa0MA9aH0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}