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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278bab36c56535754784fa133704d68461d134ed274f8f1f4f488036ac89e175' 
  AND token = 'xS1AWvVx6mmHk3CuE7A0i/tXfmHfXXU23QMfHn2rWgQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}