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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6461e14af5ad2cb9df339be435271ea59340041c264350f111711bac1199bad2' 
  AND token = 'fAJm+WKmNTC1CWdY0H7yoSMEvx3HpcM+cWm3C57YCeQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}