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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b0885fab87c015109e624f149dbc997b66948c3384f772ef8a441d29993ea90' 
  AND token = 'ESzLeqICG4hbg2+SS4WgXgdf/AXSmf8jpTlSGm6gYig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}