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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '921539ba0f7fe2293472b691842fd674ae8f623309002a720730b71759df1701' 
  AND token = 'ECy2Vt+OcqhuZMx7zRizmoF2U2tIXPx2tT6WHrf3KN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}