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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c2b9bc928701246266d8e34d81f71c48fae8180688d9062111ef24e08f0a847' 
  AND token = 'hGrPm0JIi5NwdlVG/nhdXaXXuLFBQesc1V1qy3lQXSg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}