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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df3ffd8514dd485f600d23298707c59b50d379bcb86002c11fdd516c68dc6dad' 
  AND token = 'ua/NZ16gdSFmESZugdHM5qO8kOR4U9UnEwQEzceznu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}