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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5de2904ea553414918f8d05f734cb1b0dc6a37deaea1c91e254bedbceb2d2a49' 
  AND token = 'C+8GNf/NjUHEnQlS720UDvpsi+20sch3/wFxAxKGlI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}