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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66629decd27b34df4e261d822b3e3c6e9675ce6f41cec356ab7a445b9fdc3219' 
  AND token = 'HcGtIIgr/XTpP94/JZFFmaDT45sEBKZKYPupMnxAS6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}