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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4b9c6da1e09c1156a8dfff0d7ce2af66f129b122be9689a24be3cbb811bf5d0' 
  AND token = 'HE5MCw0eaAUUdJtBZcq1ll1K2fc58+b8Ek+gSgkBEK4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}