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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78afe8a0702c3b4dcba74370bd32c77a0f1ba151cc26c4520b2f0512245e1234' 
  AND token = 'R2RLqlFzkPB9bQ1WgXX75BgkSj0G1PR742QWJ44i9Hc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}