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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21455dba31f606e83d58d6fb34f1a2e1a0407f5204d6d770dfa4327545e65e21' 
  AND token = 'NxvYbQrLHkplQp3IUeKRigHOHDNCu+GtICZT1CugebQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00076

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}