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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42efec714c34166649ab58b6232782dc5184db14f33825a26d3adec4ba98f012' 
  AND token = 'EJDD/dN3tQ1IJ6wM3dfpRJpDPbJqyLziffDeQXgN6hU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}