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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '497c6e0ce9f13538399e57a1e635e0fe199032b80b382ea4550d10078bf10550' 
  AND token = 'P/nVVoAHPorRTmHa2HKRpoHdcwGEShQTyDBtfBXZxAw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}